استفاده از مهار کننده‌ فاکتور نسخه‌برداری NF - κB در جزایر پانکراس

استفاده از مهار کننده فاکتور نسخه برداری nf - κb در جزایر پانکراس

مقدمه: پیوند جزایر پانکراس به عنوان روشی مناسب در درمان بیماران مبتلا به دیابت نوع 1 شناخته شده است. هر چند فعال شدن سایتوکین های پیش التهابی مترشحه از خود جزایر پانکراس منجر به وقایع التهابی به هم پیوسته ای می گردد که باعث از دست رفتن پیوند به طور حاد و یا مزمن می گردد. .مسیر سیگنالی nf - kb در پاسخ به استرسهای ناشی از جداسازی و تخلیص جزایر پانکراس فعال می گردد که ترشح و آزادسازی مدیاتورهای ال...

NF-κB signaling.

The NF-κB transcription factor is a critical regulator of the immune system, and is responsive to a large number of stimuli. Different stimuli engage signaling pathways to activate NF-κB, and effect distinct cellular responses. Mathematical modeling of the NF-κB network has been useful in studying the dynamic and cross-talk regulation of NF-κB. In this review, we discuss the regulation of NF-κB...

Hypoxia Induced NF-κB.

As Nuclear Factor-κB (NF-κB) is a major transcription factor responding to cellular stress, it is perhaps not surprising that is activated by hypoxia, or decreased oxygen availability. However, how NF-κB becomes activated in hypoxia is still not completely understood. Several mechanisms have been proposed and this review will focus on the main findings highlighting the molecules that have been ...

NF-κB: Ten Years After

Patrick A. Baeuerle* and David Baltimore† do not readily transform cells upon transfection. An exception is v-Rel which, however, can acutely transform *Tularik Inc. only avian cells in culture. The transforming potential Two Corporate Drive of a RelA splice variant called p65D in rodent cells reSouth San Francisco, California 94080 CA 94080 mains a matter of debate (Narajanan et al., 1992; Gri...

NF-κB in premature aging

consequence of a stochastic process caused by the accumulative effect of damaged molecules. However, recent experimental evidences have extended this view and suggested that aging also requires active signaling programs for the maintenance of the aged state [1]. Beyond cell-autonomous alterations, age signals get systemic through changes in intercellular communication pathways [2]. The identifi...

SnapShot: NF-κB Signaling Pathways